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WELCOME

By prescription only. Please see Important Safety Information about YEZTUGO^® throughout the video and see the Important Facts at Yeztugo.com, including an important warning about the risk of resistance from undetected HIV-1 infection. Ask your healthcare provider if YEZTUGO is right for you.

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Welcome! This video will give you an overview of YEZTUGO. Please see Important Safety Information throughout the video, and see the YEZTUGO Important Facts, including important warnings.

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YEZTUGO® is a prescription medicine used as HIV-1 PrEP (pre-exposure prophylaxis) to reduce the risk of getting HIV-1 in adults and adolescents who weigh at least 77 pounds. You must be HIV negative before and while receiving YEZTUGO. Talk to your healthcare provider to see if it’s right for you.

By prescription only.

ANNOUNCER:

YEZTUGO® is a prescription medicine used as HIV-1 PrEP (pre-exposure prophylaxis) to reduce the risk of getting HIV-1 in adults and adolescents who weigh at least 77 pounds. You must be HIV negative before and while receiving YEZTUGO. Talk to your healthcare provider to see if it’s right for you. 

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By prescription only. Please see Important Facts about YEZTUGO, including important warnings, at YEZTUGO.com. Ask your healthcare provider if YEZTUGO is right for you.

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Each experience may be a bit different, but let’s dive in and see what a typical YEZTUGO journey could look like.

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THE YEZTUGO CONVERSATION AND DECISION

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 Chapter 1: The YEZTUGO conversation and decision

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 Discussion

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 Step 1 is talking to your healthcare provider to see if YEZTUGO is right for you.

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Medical history, All medications, Sexual health, If you are pregnant or plan to become pregnant, If you breastfeed, Past HIV and STI test results

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They’ll ask you about your medical history, any prescription or over-the-counter medications you may take—including vitamins and supplements—your sexual health, whether you’re pregnant, planning to become pregnant, or breastfeeding, and any past HIV and STI test results. Be open and honest—they’re here to help.

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Who should not receive or take YEZTUGO? Do not receive YEZTUGO if you already have HIV or do not know your HIV status. If you have HIV, you will need to take other medicines to treat it. YEZTUGO is not approved to treat HIV and is only for reducing the risk of getting HIV before you get it.

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Who should not receive or take YEZTUGO? Do not receive YEZTUGO if you already have HIV or do not know your HIV status. If you have HIV, you will need to take other medicines to treat it. YEZTUGO is not approved to treat HIV and is only for reducing the risk of getting HIV before you get it.

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What should I tell my healthcare provider before receiving YEZTUGO? • All your medical conditions. • If you are pregnant or plan to become pregnant. Tell your healthcare provider if you become pregnant while or after receiving YEZTUGO. • If you are breastfeeding or plan to breastfeed. Talk to your healthcare provider about the best way to feed your baby while you are receiving YEZTUGO. • All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. YEZTUGO can remain in your body for up to 9 months after your last injection and can affect other medicines. Keep a list of all your medicines and show it to your healthcare provider and pharmacist. Do not start a new medicine without telling your healthcare provider.

ANNOUNCER:

What should I tell my healthcare provider before receiving YEZTUGO? • All your medical conditions. • If you are pregnant or plan to become pregnant. Tell your healthcare provider if you become pregnant while or after receiving YEZTUGO. • If you are breastfeeding or plan to breastfeed. Talk to your healthcare provider about the best way to feed your baby while you are receiving YEZTUGO. • All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. YEZTUGO can remain in your body for up to 9 months after your last injection and can affect other medicines. Keep a list of all your medicines and show it to your healthcare provider and pharmacist. Do not start a new medicine without telling your healthcare provider.

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If you and your healthcare provider decide that YEZTUGO might be an option for you...

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HIV TEST

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…they’ll ask you to complete and HIV test.

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HIV-NEGATIVE RESULTS

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YEZTUGO is only for people who are HIV negative, and is used to reduce the risk of getting HIV-1.

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NEGATIVE

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If the result is negative, they’ll prescribe YEZTUGO and begin the process for you to receive it.

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IMPORTANT SAFETY INFORMATION

What is the most important information I should know about YEZTUGO?

Before and while receiving YEZTUGO:

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IMPORTANT SAFETY INFORMATION

What is the most important information I should know about YEZTUGO?

Before and while receiving YEZTUGO:

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IMPORTANT SAFETY INFORMATION

What is the most important information I should know about YEZTUGO?

Before and while receiving YEZTUGO:

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• YEZTUGO is not approved to treat HIV. You must immediately take other medicines if you get HIV. If you have HIV and only receive YEZTUGO, your HIV may become harder to treat. •Follow the YEZTUGO dosing schedule, which includes returning to a healthcare provider for your scheduled injections every 6 months. Missing scheduled injections or tablets can increase your chances of getting HIV. •To further help reduce your risk of getting HIV: •Know your HIV status and the HIV status of your partner(s). If they are living with HIV, your risk of getting HIV is lower if they are taking effective HIV treatment. •Talk to your healthcare provider about all the ways to help reduce the risk of getting HIV.

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Additional Steps

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Your healthcare provider will have some additional steps they need to take to make sure you can get the medication—let’s talk about that.

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COVERAGE & APPROVAL

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Chapter 2: Coverage and approval

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Benefits Verification, Prior Authorization

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After your healthcare provider prescribes YEZTUGO, there are 2 steps they may take—benefits verification and prior authorization.

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Benefits verification is when a healthcare provider checks if insurance covers a prescription.

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Benefits verification means checking if your insurance will cover a medication, like YEZTUGO. This step typically takes about 1 to 3 days.

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Prior authorization is when an insurance company requests additional information from a healthcare provider to determine medication coverage.

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Prior authorization is when an insurance company requests additional information from a healthcare provider to determine medication coverage.

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Process may take about 14 to 28 days

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Your healthcare provider will gather the list of requirements for this step. This process may take a little longer, sometimes between 14 to 28 days.

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You can reach out to your healthcare provider’s office if you have questions about either of these steps.

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ADVANCING ACCESS^®

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If you have questions about insurance coverage or financial support options, Gilead Advancing Access may be able to help. They can help you understand your coverage and financial support options.

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PrEP.AdvancingAccess.com

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Visit PrEP.AdvancingAccess.com to learn more.

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GETTING YEZTUGO

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Chapter 3: Getting YEZTUGO

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Once the prior authorization is approved, your healthcare provider will work with you on getting started with YEZTUGO.

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YEZTUGO must be injected in a medical setting by a healthcare professional.

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HEALTHCARE PROVIDER

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So talk with your healthcare provider about where you’ll get the injection.

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HEALTHCARE PROVIDER

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It might be at their office or at another location.

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The way your healthcare provider gets the medication may vary depending on the office.

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If they prescribe YEZTUGO through a specialty pharmacy...

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SPECIALTY PHARMACY The specialty pharmacy will reach out to you or your healthcare provider about payment and delivery.

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...the specialty pharmacy will reach out to you or your healthcare provider about payment and delivery.

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Be sure to confirm the address where you’ll be given your YEZTUGO injections.

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Be sure to confirm with the specialty pharmacy the address where you’ll be given your YEZTUGO injections.

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HEALTHCARE PROVIDER, SPECIALTY PHARMACY

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If you don’t know the address, ask your healthcare provider’s office.

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HEALTHCARE PROVIDER, SPECIALTY PHARMACY

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Your healthcare provider will work with the specialty pharmacy to make sure that YEZTUGO is shipped, received, and ready. They will also reach out to you about scheduling your next injection.

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Delivery of YEZTUGO can take about 30 days once a prescription is ordered.

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Delivery of YEZTUGO can take about 30 days once a prescription is ordered.

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ADVANCING ACCESS^®

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After the YEZTUGO prescription is written, Gilead Advancing Access can help you navigate the next steps.

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IT TAKES 2

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Chapter 4: It takes 2

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2X YEARLYYEZTUGO IS GIVEN EVERY 6 MONTHS One office visit, every six months. Two injections per visit, after starter dosing.

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YEZTUGO is given every 6 months.

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APPT. DAY BRING YOUR MEDICAL INSURANCE AND PRESCRIPTION INSURANCE INFORMATION

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On the day of your appointment, it’s important to bring your health insurance and prescription insurance information with you.

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1st YEZTUGO APPOINTMENT YOUR FIRST YEZTUGO APPOINTMENT INCLUDES AN ORAL STARTER DOSE

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Your first appointment for YEZTUGO will include a starter dose, which is only taken when you’re first starting YEZTUGO.

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YEZTUGO STARTER DOSING

DAY 1 in office 2 pills + 2 injections 600 mg orally (2 x 300-mg tablets) 927-mg subcutaneous injection (2 x 1.5-mL injections)

DAY 2 at home 2 pills only 600 mg orally (2 x 300-mg tablets)

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On your first day with YEZTUGO, you’ll take a starter dose which includes two pills taken by mouth, and receive two injections of YEZTUGO at your healthcare provider’s office. This is followed by two more pills taken at home the next day.

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REMEMBER TO TAKE THOSE LAST 2 PILLS

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Make sure you remember to take those last 2 pills the day after your injection, as the medication needs to be taken exactly as prescribed. Talk to your healthcare provider if you have any questions about taking YEZTUGO.

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After YEZTUGO is injected it stays under the skin and slowly releases over time. Some people may see or feel a bump at the injection site while others may not. YEZTUGO works regardless.

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After YEZTUGO is injected it stays under the skin and slowly releases over time. Some people may see or feel a bump at the injection site while others may not. YEZTUGO works regardless.

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What are the possible side effects of YEZTUGO?

• The most common side effects of YEZTUGO are injection site reactions, headache, and nausea. These are not the only possible side effects. •Reactions at the injection site may include a lump or bump, pain, skin hardening, swelling, itching, redness, bruising, or warmth.•Rarely, if YEZTUGO is injected incorrectly, serious injection site reactions, like severe damage of the skin or open sores, can occur. Tell your healthcare provider if you have any injection site reactions or other side effects that bother you or don’t go away.

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What are the possible side effects of YEZTUGO?

• The most common side effects of YEZTUGO are injection site reactions, headache, and nausea. These are not the only possible side effects. •Reactions at the injection site may include a lump or bump, pain, skin hardening, swelling, itching, redness, bruising, or warmth.•Rarely, if YEZTUGO is injected incorrectly, serious injection site reactions, like severe damage of the skin or open sores, can occur. Tell your healthcare provider if you have any injection site reactions or other side effects that bother you or don’t go away.

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STAYING ON SCHEDULE WITH YEZTUGO

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Chapter 5: Staying on schedule with YEZTUGO

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2X YEARLY Staying on schedule is key to HIV prevention with YEZTUGO. One office visit, every six months. Two injections per visit, after starter dosing.

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Staying on schedule is key to HIV prevention with YEZTUGO.

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2-WEEK WINDOW

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Each dose of 2 injections is scheduled with your healthcare provider up to 2 weeks before or 2 weeks after your 6-month mark—meaning 6 months or 26 weeks after your last injections. It’s important to attend all appointments with your healthcare provider.

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HIV prevention requires regular HIV testing.

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STAYING ON YOUR 6-MONTH YEZTUGO SCHEDULE REQUIRES REGULAR HIV TESTING AND NEGATIVE RESULTS

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To stay on your 6-month YEZTUGO schedule, your healthcare provider will require a negative HIV test before each injection and additionally as needed. Talk with them to learn more.

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You must be HIV negative before you start and while receiving YEZTUGO. Get an HIV test before starting, before each injection, and when your healthcare provider tells you. If you think you were exposed to HIV while receiving YEZTUGO, talk to your healthcare provider as you may need an HIV test.

ANNOUNCER:

You must be HIV negative before you start and while receiving YEZTUGO. Get an HIV test before starting, before each injection, and when your healthcare provider tells you. If you think you were exposed to HIV while receiving YEZTUGO, talk to your healthcare provider as you may need an HIV test.

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They’ll also use those test results as part of the paperwork they send to your insurance company.

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That’s it!

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And that’s it! Please refer to this video from time to time if you need a refresher. For any other questions, talk to your healthcare provider.

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If you have questions about insurance coverage or financial support options, visit Prep.AdvancingAccess.com to learn more.

Gilead Advancing Access lock up. PrEP.AdvancingAccess.com

ANNOUNCER:

If you have questions about insurance coverage or financial support options, visit Prep.AdvancingAccess.com to learn more.

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What is YEZTUGO?

YEZTUGO is a prescription medicine used as HIV-1 PrEP (pre-exposure prophylaxis) to reduce the risk of getting HIV-1 in adults and adolescents who weigh at least 77 pounds. You must be HIV negative before and while receiving YEZTUGO.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about YEZTUGO?

Before and while receiving YEZTUGO:

• You must be HIV negative before you start and while receiving YEZTUGO. Get an HIV test before starting, before each injection, and when your healthcare provider tells you. If you think you were exposed to HIV while receiving YEZTUGO, talk to your healthcare provider as you may need an HIV test.

ANNOUNCER:

What is YEZTUGO?

YEZTUGO is a prescription medicine used as HIV-1 PrEP (pre-exposure prophylaxis) to reduce the risk of getting HIV-1 in adults and adolescents who weigh at least 77 pounds. You must be HIV negative before and while receiving YEZTUGO.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about YEZTUGO?

Before and while receiving YEZTUGO:

• You must be HIV negative before you start and while receiving YEZTUGO. Get an HIV test before starting, before each injection, and when your healthcare provider tells you. If you think you were exposed to HIV while receiving YEZTUGO, talk to your healthcare provider as you may need an HIV test.

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• You must be HIV negative before you start and while receiving YEZTUGO. Get an HIV test before starting, before each injection, and when your healthcare provider tells you. If you think you were exposed to HIV while receiving YEZTUGO, talk to your healthcare provider as you may need an HIV test.

• Some HIV tests may not detect HIV in a person who recently acquired HIV. Tell your healthcare provider if you had a flu-like illness within the last month before starting or while receiving YEZTUGO. Symptoms of new HIV infection include tiredness, fever, joint or muscle aches, headache, sore throat, vomiting or diarrhea, rash, night sweats, and/or enlarged lymph nodes in the neck or groin.

• YEZTUGO does not prevent other sexually transmitted infections (STIs). Get tested for other STIs and practice safer sex by using condoms to reduce the risk of getting STIs.

• YEZTUGO is not approved to treat HIV. You must immediately take other medicines if you get HIV. If you have HIV and only receive YEZTUGO, your HIV may become harder to treat.

• Follow the YEZTUGO dosing schedule, which includes returning to a healthcare provider for your scheduled injections every 6 months. Missing scheduled injections or tablets can increase your chances of getting HIV.

• To further help reduce your risk of getting HIV:

• Know your HIV status and the HIV status of your partner(s). If they are living with HIV, your risk of getting HIV is lower if they are taking effective HIV treatment.

ANNOUNCER:

• You must be HIV negative before you start and while receiving YEZTUGO. Get an HIV test before starting, before each injection, and when your healthcare provider tells you. If you think you were exposed to HIV while receiving YEZTUGO, talk to your healthcare provider as you may need an HIV test.

• Some HIV tests may not detect HIV in a person who recently acquired HIV. Tell your healthcare provider if you had a flu-like illness within the last month before starting or while receiving YEZTUGO. Symptoms of new HIV infection include tiredness, fever, joint or muscle aches, headache, sore throat, vomiting or diarrhea, rash, night sweats, and/or enlarged lymph nodes in the neck or groin.

• YEZTUGO does not prevent other sexually transmitted infections (STIs). Get tested for other STIs and practice safer sex by using condoms to reduce the risk of getting STIs.

• YEZTUGO is not approved to treat HIV. You must immediately take other medicines if you get HIV. If you have HIV and only receive YEZTUGO, your HIV may become harder to treat.

• Follow the YEZTUGO dosing schedule, which includes returning to a healthcare provider for your scheduled injections every 6 months. Missing scheduled injections or tablets can increase your chances of getting HIV.

• To further help reduce your risk of getting HIV:

• Know your HIV status and the HIV status of your partner(s). If they are living with HIV, your risk of getting HIV is lower if they are taking effective HIV treatment.

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• Talk to your healthcare provider about all the ways to help reduce the risk of getting HIV.

Who should not receive or take YEZTUGO?

• Do not receive YEZTUGO if you already have HIV or do not know your HIV status. If you have HIV, you will need to take other medicines to treat it. YEZTUGO is not approved to treat HIV and is only for reducing the risk of getting HIV before you get it.

What are the possible side effects of YEZTUGO?

• The most common side effects of YEZTUGO are injection site reactions, headache, and nausea. These are not the only possible side effects.

• Reactions at the injection site may include a lump or bump, pain, skin hardening, swelling, itching, redness, bruising, or warmth.

• Rarely, if YEZTUGO is injected incorrectly, serious injection site reactions, like severe damage of the skin or open sores, can occur.

• Tell your healthcare provider if you have any injection site reactions or other side effects that bother you or don’t go away.

What should I tell my healthcare provider before receiving YEZTUGO?

ANNOUNCER:

• Talk to your healthcare provider about all the ways to help reduce the risk of getting HIV.

Who should not receive or take YEZTUGO?

• Do not receive YEZTUGO if you already have HIV or do not know your HIV status. If you have HIV, you will need to take other medicines to treat it. YEZTUGO is not approved to treat HIV and is only for reducing the risk of getting HIV before you get it.

What are the possible side effects of YEZTUGO?

• The most common side effects of YEZTUGO are injection site reactions, headache, and nausea. These are not the only possible side effects.

• Reactions at the injection site may include a lump or bump, pain, skin hardening, swelling, itching, redness, bruising, or warmth.

• Rarely, if YEZTUGO is injected incorrectly, serious injection site reactions, like severe damage of the skin or open sores, can occur.

• Tell your healthcare provider if you have any injection site reactions or other side effects that bother you or don’t go away.

What should I tell my healthcare provider before receiving YEZTUGO?

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• All your medical conditions.

• If you are pregnant or plan to become pregnant. Tell your healthcare provider if you become pregnant while or after receiving YEZTUGO.

• If you are breastfeeding or plan to breastfeed. Talk to your healthcare provider about the best way to feed your baby while you are receiving YEZTUGO.

• All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. YEZTUGO can remain in your body for up to 9 months after your last injection and can affect other medicines. Keep a list of all your medicines and show it to your healthcare provider and pharmacist. Do not start a new medicine without telling your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Important Facts about YEZTUGO, including important warnings, at Yeztugo.com.

YEZTUGO, the YEZTUGO Logo, ADVANCING ACCESS, the ADVANCING ACCESS Logo, GILEAD, and the GILEAD Logo are trademarks of Gilead Sciences, Inc., or its related companies.

©2025 Gilead Sciences, Inc. All rights reserved.

333 Lakeside Drive, Foster City, CA 94404

US-YTGC-0141 01/26

ANNOUNCER:

• All your medical conditions.

• If you are pregnant or plan to become pregnant. Tell your healthcare provider if you become pregnant while or after receiving YEZTUGO.

• If you are breastfeeding or plan to breastfeed. Talk to your healthcare provider about the best way to feed your baby while you are receiving YEZTUGO.

• All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. YEZTUGO can remain in your body for up to 9 months after your last injection and can affect other medicines. Keep a list of all your medicines and show it to your healthcare provider and pharmacist. Do not start a new medicine without telling your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Important Facts about YEZTUGO, including important warnings, at Yeztugo.com.

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Please see Important Facts about YEZTUGO, including important warnings, at Yeztugo.com. Ask your healthcare provider if YEZTUGO is right for you.

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